VersaBase Cream is a stable, pharmaceutically elegant base that can accommodate a broad range of active ingredients for customized, patient-specific medications. Compounding pharmacies have been using it for many applications over the years, but where it stands out is in topical and vaginal hormone replacement therapy (HRT). Our Clinical Services, R&D and Formulation Development departments continually research, test and formulate with VersaBase Cream, and independent researchers have worked with it as well. This makes it one of the most studied bases in the pharmacy compounding industry with a substantial portfolio of supporting data and materials, giving compounders incredible support in using it to help their patients.

 VersaBase by the Numbers

• 5 publications to support its use in compounded medications
• 230+ formulas, offering a plethora of potential treatment options
• 20 formulas with extended beyond-use dates (BUDs)
• 13 bracketed formulas with extended BUDs to expand the possibilities for pharmacy and patient
• 7 related marketing resources to help in discussions with prescribers]

It’s Been Studied
Both PCCA and independent researchers have been studying VersaBase Cream for over a decade, giving compounders support when they recommend it in compounded medications. It has been included in the Journal of Women’s Health Care, where a peer-reviewed, in vitro study showed that it delivered our Special Micronized Progesterone into and through human skin. An independent, peer-reviewed study published in Gynecologic and Obstetric Investigation evaluated the absorption of estriol, estradiol, progesterone, DHEA and testosterone in VersaBase Cream, among other experimental factors. The International Journal of Pharmaceutical Compounding recently published an independent case study showing transdermal delivery of testosterone in this base, and another study evaluating the chemical stability of a range of estriol concentrations in a VersaBase vaginal cream. U.S. Pharmacist has also published an independently developed compounding formulation of progesterone in this base.

It’s Backed by Numerous Formulas
Not only is VersaBase Cream well studied, but we have also supported it with numerous formulations as well, offering compounders, practitioners and patients a host of potential treatment options. We have developed over 230 formulas in total that use VersaBase Cream. Of those, 20 have gone through our FormulaPlus™ program, so they have extended BUDs supported by stability-indicating assays. This can save compounders thousands of dollars in stability testing, it makes compounds more convenient for patients because they won’t need to refill prescriptions as often. We provide the data behind each BUD study as well. Of those formulas, 13 are bracketed, meaning that they offer the compounder a range of active ingredient concentrations with the same extended BUD, substantially expanding their value for the pharmacy and the patient. PCCA members can easily access all of these under the formula tab of the VersaBase Cream page on the Members-Only Website. 

It Has Marketing Support
We have also developed various marketing materials to help pharmacies that compound topical and vaginal HRT with VersaBase Cream. PCCA members have access to the product information sheet, customizable top formula cards, a customizable PowerPoint presentation and much more. They can find all of them on the Marketing Resources page of the Members-Only Website.

If PCCA members have questions about compounding with VersaBase Cream, they can contact our Clinical Services department at 800.331.2498.

These statements are provided for educational purposes only. They have not been evaluated by the Food and Drug Administration, and are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment.