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By Maria Carvalho, PharmD, MRPharmS, PhD, Manager of PCCA Science
Compounding case studies describe successful patient treatments and provide scientific evidence to support the safety and efficacy of compounded medications. When case studies are published in peer-reviewed journals, pharmacists and clinicians worldwide become aware of innovative ways to treat their patients. One case study alone may improve the lives of many patients. That’s why we on the PCCA Science team work with compounders around the world to develop clinical case studies and publish them.
PCCA member Dr. Kelechi Agbi recently published two case studies featuring PCCA Sorbitol Lollipop™ base in the International Journal of Pharmaceutical Compounding. Researchers at PCCA’s United Kingdom location also completed a case study on two veterinary patients who were successfully treated with a Lipoderm® formula. You can find summaries of these studies below. More journal articles related to compounding will soon be published — stay tuned for more PCCA Science updates here on The PCCA Blog!
Study : Glycopyrrolate Sorbitol Lollipops for Drooling: Two Case Reports
Authors : Kelechi E. Agbi (Agbi’s Compounding Pharmacy, Pikesville, Maryland), Maria Carvalho and Fabiana Vieira-Banov (PCCA, Houston, Texas)
Publication : International Journal of Pharmaceutical Compounding, 25(6), 464-467
Summary : A patient with dementia and a patient with cancer both experienced persistent drooling, an issue that negatively affected their quality of life. They were both prescribed glycopyrrolate 0.5 mg sorbitol lollipops. During treatment, each of them experienced substantial decreases in the severity and frequency of drooling without any adverse effects. These two case reports demonstrate the safety and efficacy of compounded glycopyrrolate lollipops for managing excessive salivation.
For more information on the technology behind the base used in this study, visit the PCCA Sorbitol Lollipop product page on PCCA’s website.
Study : Veterinary: Behaviour Disorders in Cats
Author : PCCA United Kingdom
Publication : PCCA Website (PCCA Document #99918)
Summary : Two cats, Charlie and Isobelle, tended to urinate and defecate in inappropriate locations around their house in the absence of their owner. These behavior issues, commonly attributed to separation-related problems, happened up to 10 times a day. Their veterinarian prescribed fluoxetine as tablets and as an oral liquid, but the cats refused both dosage forms. The veterinarian then prescribed a permeation-enhancing topical compounded medicine (fluoxetine 40 mg/Gm in Lipoderm) to be applied 0.1 mL inside the ear of the cats once daily. Following one month of treatment, the cats were no longer showing signs of emotional distress, and their behavior and wellbeing improved considerably.
For more information on the technology behind the base used in this study, visit the PCCA Lipoderm product page on our website.
The full list of PCCA case studies, and many others scientific publications, is available on the PCCA Science webpage under “ Scientific Publications .”
Compounding pharmacists are on the therapeutic front lines every day and commonly hear success stories from their patients. Don’t miss the opportunity to share these stories! PCCA Science provides our members with full support in developing and writing clinical case studies. For more information on how to start a case study with us, please visit the PCCA Science webpage and click “ Initiate Case Study ” or contact us at PCCAScience@pccarx.com.
Also on The PCCA Blog: Scientific Posters Supporting the Safety and Efficacy of Compounds
Maria Carvalho, PharmD, MRPharmS, PhD, is the manager of PCCA Science. She is a certified pharmacist in Portugal and the United Kingdom with a PhD in pharmaceutical compounding from the University College of London. Maria has worked in community pharmacy, hospital pharmacy and the pharmaceutical industry in Europe and the United States. Maria has authored and co-authored many scientific publications, including the book Compounding Practices in Europe (ISBN-10:149236925X).
These statements are provided for educational purposes only. They have not been evaluated by the Food and Drug Administration, and are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment.