As compounders, we work with a variety of active pharmaceutical ingredients (APIs), some of which are more challenging to compound than others. Compounding with methylene blue as an API has risen due to emerging research for a variety of clinical applications. However, methylene blue can be intimidating to compound due to its intense blue color, which may stain costly lab equipment, countertops and other materials. Discover some useful techniques that can ease the sometimes stressful process of working with this vibrant API.